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Developing a Guideline for Reporting Mediation Analyses (AGReMA) in randomized trials and observational studies

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The Guideline for Reporting Mediation Analyses (AGReMA) is an evidence- and consensus-based guideline that provides recommendations for reporting primary and secondary mediation analyses of randomized trials and observational studies. It is designed to assist authors, peer-reviewers, and journal editors to ensure accurate, consistent, and transparent reporting of studies that use mediation analyses.

The AGReMA initiative followed the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network methodological framework, including a consensus meeting with methodologists, statisticians, clinical trialists, epidemiologists, psychologists, clinical researchers, clinicians, implementation scientists, evidence synthesis experts, representatives of the EQUATOR network, and journal editors. Learn more and find AGReMA checklists at

Publications associated with this project:

  • Lee, Hopin, Aidan G. Cashin, Sarah E. Lamb, Sally Hopewell, Stijn Vansteelandt, Tyler J. VanderWeele, David P. MacKinnon, et al. “A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement.” JAMA 326, no. 11 (September 21, 2021): 1045–56.
  • Cashin, Aidan G., James H. McAuley, Sarah E. Lamb, Sally Hopewell, Steven J. Kamper, Christopher M. Williams, Nicholas Henschke, and Hopin Lee. “Development of A Guideline for Reporting Mediation Analyses (AGReMA).” BMC Medical Research Methodology 20, no. 1 (February 3, 2020): 19.
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